When Propofol is Problematic
نویسنده
چکیده
Figure 1. Representation of the electron transport chain showing the relationship of complexes I-V. Note that I and II both feed into III via the intermediate ubiquinone. Cytochrome c then receives electrons from III and passes them to complex IV. Electron flow is linked to protons pumped out of the matrix (dotted arrows). Proton gradient drives ATP formation by F0F1 ATPase (complex V). Propofol inhibits mitochondrial function at multiple sites.
منابع مشابه
تاثیر مخلوط کردن پروپوفول و تیوپنتال بر روی تغییرات همودینامیک، درد زمان تزریق و دوز خوابآور در زمان القای بیهوشی: مطالعه آیندهنگر دوسوکور
Background: Propofol and Thiopental are intravenous anesthetics having relatively different hemodynamic influences and adverse effects. In addition, there is significant pain on intravenous injection of propofol. This study was performed to examine the effects of Propofol-Thiopental admixture on hemodynamic variables, pain on injection and hypnotic dose at the time of induction of general anest...
متن کاملCARING FOR THE CRITICALLY ILL PATIENT Dexmedetomidine vs Midazolam or Propofol for SedationDuringProlongedMechanicalVentilation Two Randomized Controlled Trials
SEDATION IN INTENSIVE CARE PAtients is assumed to reduce discomfort from care interventions, increase tolerance of mechanical ventilation, prevent accidental removal of instrumentation, and reduce metabolic demands during cardiovascular and respiratory instability. Long-term sedation may have serious adverse effects, such as prolonged mechanical ventilation, coma, delirium, delusional memories ...
متن کاملمقایسه تاثیر پروپوفول- فنتانیل و کتامین- فنتانیل بر علایم حیاتی، آرامش و بیدردی بیماران کاندید کارگذاری کاتاتر پرمکت
Abstract Background: The aim of this study was comparison of sedation and analgesia between two drug combinations i.e. propofol+ fentanyl and ketamine+fentanyl, in patients with End stage renal disease, (ESRD) who were candidates for insertion of ‘Perm Cath’ catheter for the purpose of hemodialysis. Methods: Fifty one candidates for ‘perm cath’ catheter insertion were enrolled in this st...
متن کاملمقایسه اثر نسبت های مختلف پروپوفول و کتامین بر تغییرات همودینامیکی بیماران در هنگام القا بی هوشی
Background and purpose: The aim of this prospective, clinical trial study was to investigate whether the administration of different doses of ketamine before induction with propofol imporves its associated haemodynamic propofol during induction and tracheal intubation. Materials and Methods: One hundered and thirty adult patients ASA I were randomly allocated to one of six groups to receiv...
متن کاملمقایسه اثربخشی متوکلوپروماید و لیدوکائین در کاهش میزان بروز و شدت درد هنگام تزریق پروپوفول، بیمارستان شریعتی، 1381
One of the disturbing complications of propofol is pain on injection and the incidence ranges from 28% to 90%. Metoclopromide is commonly used as an anti emetic drug. Some investigators reported that this drug could reduce the pain on injection of propofol. The aim of this study was to assess and comparison of the efficacy of propofol pretreatment with metoclopromide in incidence and severity o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007